Special Advisor To The President - Matteo Cesari

PERSONAL INFORMATION

 

Name CESARI MATTEO

Office Telephone +39 02 5032 0735

 

WORK EXPERIENCE

 

2017-present Associate Professor of Geriatrics, Università degli Studi di Milano (Milan, Italy)

2019-present Director of the Geriatric Fellowship Program, Università degli Studi di Milano (Milan, Italy)

2017-present Director, Geriatric Unit, Fondazione Ca’ Granda – Ospedale Maggiore Policlinico (Milan, Italy)

2015-present Consultant for the World Health Organization (WHO, Geneva, Switzerland) on aging and age-related conditions. Member of the WHO Clinical Consortium on Healthy Ageing.

2012-2017 Associate Professor, Université de Toulouse III Paul Sabatier (Toulouse, France)

2011-2017 Consultant, Gérontopôle, Centre Hospitalier Universitaire de Toulouse (Toulouse, France)

2009-2011 Geriatrician, Area di Geriatria, Università Campus Biomedico (Roma, Italy)

2008-2009 Geriatrician, Centro Medicina dell’Invecchiamento, Università Cattolica del Sacro Cuore (Roma, Italy)

2007-2008 Research Assistant Professor, Department of Aging and Geriatric Research, University of Florida (Gainesville, FL, USA)

2005-2007 Lecturer, Department of Aging and Geriatric Research, University of Florida (Gainesville, FL, USA)

2004-2005 Instructor, Sticht Center on Aging, Wake Forest University (Winston Salem, NC, USA)

2002-2004 Research Associate, Sticht Center on Aging, Wake Forest University (Winston Salem, NC, USA)

 

EDUCATION AND TRAINING

2017 Habilitation at the role of Professor of Geriatrics (MED09) provided by the Italian Ministry of Education, University and Research (MIUR)

2013 Habilitation at the role of Associate Professor of Geriatrics (MED09) provided by the Italian Ministry of Education, University and Research (MIUR)

2012 Habilitation à Diriger des Recherches (HDR) at the Université de Toulouse III Paul Sabatier (Toulouse, France)

1999-2001, 2003-2006 Geriatric fellowship at the Università Cattolica del Sacro Cuore (Roma, Italy)

2004 Summer course in Principles of Epidemiology at the Bloomberg School of Public Health – Johns Hopkins University (Baltimore, MD, USA)

2004 Summer course in Statistical Reasoning in Public Health I and II at the Bloomberg School of Public Health - Johns Hopkins University (Baltimore, MD, USA)

2001-2003 Research Doctorate (PhD) on “Preventive Medicine in the Elderly”at the Università Cattolica del Sacro Cuore (Roma, Italy)

1999 Medical Doctor at the Università Cattolica del Sacro Cuore (Roma, Italy)

1993 Bachelor of Arts in Physics and Natural Sciences at the Collegio San Giuseppe – Istituto De Merode (Roma, Italy)

 

PERSONAL SKILLS AND COMPETENCES

LANGUAGES Italian (mothertongue), English (fluent), French (fluent)

 

TECHNICAL SKILLS AND COMPETENCES Operating systems: Windows, Mac, Proficient in the use of the following software programs: SPPS, Stata, Microsoft Office

 

MEDICAL LICENSE(S)

Italy (registered at the Board of Medical Doctors of Milan since October 18, 2017 with the ID#45258)

Previously registered at the Board of Medical Doctors of Rome (2000-2012; ID#50407) and Toulouse (2012-2017; ID #12427, RPPS 10100316412)

EDITORIAL WORK

2011-present Editor-in-Chief of Journal of Frailty & Aging

2019-present Senior Associate Editor of the Journal of the American Medical Directors Association (JAMDA)

2014-present Associate Editor of Frontiers in Geriatric Medicine

2017-2019 Associate Editor of JAMDA

2014-2018 Associate Editor of the Journals of Gerontology: Series A Medical Sciences

Member of the Editorial Board of several scientific journals, including Aging Clinical Experimental Research (February 2019- present), Journal of the American Geriatrics Society (September 2017-present), Journal of Nutrition, Health and Aging (2017-present), and Journals of Gerontology Medical Sciences (2019-present)

PUBLICATIONS

Listed by Thomson Reuters/Clarivate Analytics among The World’s Most Influential Scientific Minds/Highly Cited Researchers since 2014.

The publication includes the name of researchers who published the greatest number of highly cited scientific papers. Highly cited papers are those ranking in the top 1% by citations for their field and year of publication.

Author of more than 400 publications in peer-reviewed scientific journals (h-index: 64), more than 200 abstracts presented at national and international scientific meetings, 17 book chapters (8 in English, 9 in Italian), and several divulgation articles

More than 150 oral presentations at national and international scientific meetings (more than 100 as invited speaker).

A selection of peer-reviewed publications is listed in the Annex.

RESEARCH FUNDING

Dr. Cesari’s research activities have been funded by major private and public institutions, including the European Commission (Bruxelles, Belgium), the Innovative Medicines Initiatives (Bruxelles, Belgium), the US National Institute on Aging (Bethesda, MD, USA), the Swissbridge Foundation, (Zurich, Switzerland), the Agence Nationale de la Recherche (Paris, France), and the Italian Ministry for University, Scientific Research and Technology (Rome, Italy) A selection of funded research projects is listed in the Annex.

 

Milan (Italy) – January 20, 2020

Matteo Cesari, MD, PhD


 

 

ANNEX

 

Selected peer-reviewed publications (out of more than 450 articles published in peer-reviewed scientific journals)

 

1.       Cesari M, Vanacore N, Agostoni C. The two extremes meet: pediatricians, geriatricians and the life-course approach. Pediatr Res. 2019 Jun 25. doi:10.1038/s41390-019-0479-4.

2.       Vezza C, Vettoretti S, Caldiroli L, Bergamaschini L, Messa P, Cesari M. Use of the Frailty Index in Older Persons With Chronic Kidney Disease. J Am Med Dir Assoc. 2019 Jun 5. pii: S1525-8610(19)30376-7. doi: 10.1016/j.jamda.2019.04.015.

3.       Canevelli M, Bruno G, Grande G, Quarata F, Raganato R, Remiddi F, Valletta M, Zaccaria V, Vanacore N, Cesari M. Race reporting and disparities in clinical trials on Alzheimer's disease: A systematic review. Neurosci Biobehav Rev. 2019 Jun;101:122-128.

4.       Cesari M, Araujo de Carvalho I, Amuthavalli Thiyagarajan J, Cooper C, Martin FC, Reginster JY, Vellas B, Beard JR. Evidence for the Domains Supporting the Construct of Intrinsic Capacity. J Gerontol A Biol Sci Med Sci. 2018;73(12):1653-1660.

5.       Cesari M, Pérez-Zepeda MU, Marzetti E. Frailty and multimorbidity: different ways of thinking about geriatrics. J Am Med Dir Assoc 2017;18(4):361-364.

6.       Cesari M, Landi F, Calvani R, Cherubini A, Di Bari M, Kortebein P, Del Signore S, Le Lain R, Vellas B, Pahor M, Roubenoff R, Bernabei R, Marzetti E, on behalf of the SPRINTT Consortium. Rationale for a preliminary operational definition of physical frailty and sarcopenia in the SPRINTT trial. Aging Clin Exp Res 2017;29(1):81-88.

7.       Cesari M, Marzetti E, Thiem U, Perez Zepeda MU, Abellan van Kan G, Landi F, Petrovic M, Cherubini A, Bernabei R. The geriatric management of frailty as paradigm of “the end of the disease era”. Eur J Intern Med 2016;31:11-14

8.       Cesari M, Costa N, Hoogendijk EO, Vellas B, Canevelli C, Perez Zepeda MU. How the Frailty Index may support the allocation of healthcare resources – An example from the INCUR study. J Am Med Direct Assoc 2016;17(5):448-450

9.       Cesari M, Prince M, Amuthavalli Thiyagarajn J, Araujo de Carvalho I, Bernabei R, Chan P, Gutierrez-Robledo LM, Michel JP, Morley JE, Ong P, Rodriguez Manas L, Sinclair A, Won CW, Beard JR, Vellas B. Frailty – An emerging public health priority. J Am Med Dir Assoc 2016;17(3):188-192

10.   Cesari M, Vanacore N, Canevelli M. What are we willing to accept for preventing Alzheimer’s disease? Lancet Neurol 2016 Jun;15(7):659-660

11.   Cesari M, Vellas B. Frailty in clinical practice. Nestle Nutr Inst Workshop Ser 2015;83:93-8

12.   Teguo MT, Kuate-Tegueu C, Dartigues JF, Cesari M. Frailty in sub-Saharan Africa. Lancet 2015;385(9983):2151

13.   Cesari M, Vellas B, Hsu FC, et al, for the LIFE study group. A physical activity intervention to treat the frailty syndrome in older persons – Results from the LIFE-P study. J Gerontol A Biol Sci Med Sci 2015;70(2):216-222

14.   Kelaiditi E, Guyonnet S, Cesari M. Is nutrition important to postpone frailty? Curr Opin Clin Nutr Metab Care 2015;18(1):37-42

15.   Cesari M, Gambassi G, Van Kan GA, Vellas B. The frailty phenotype and the frailty index: different instruments for different purposes. Age Ageing 2014;43:10-2

16.   Cesari M, Landi F, Vellas B, Bernabei R, Marzetti E. Sarcopenia and physical frailty: two sides of the same coin. Front Aging Neurosci 2014;6:192

17.   Cesari M, Cerullo F, Zamboni V, et al. Functional status and mortality in older women with gynecological cancer. J Gerontol A Biol Sci Med Sci 2013;68:1129-33

18.   Cesari M, Vellas B, Gambassi G. The stress of aging. Exp Gerontol 2013;48:451-6

19.   Cesari M, Vellas B. Sarcopenia: a novel clinical condition or still a matter for research? J Am Med Direct Assoc 2012;13:766-767 [Editorial]

20.   Cesari M, Antonelli Incalzi R, Kritchevsky SB, et al. Oxidative damage, platelet activation, and inflammation to predict mobility disability and mortality in older persons: results from the Health Aging and Body Composition study. J Gerontol A Biol Sci Med Sci 2012;67:671-6

21.   Cesari M, Pedone C, Chiurco L, et al. Physical performance, sarcopenia and respiratory function in older patients with chronic obstructive pulmonary disease. Age Ageing 2012;41:237-41

22.   Cesari M, Fielding RA, Pahor M, et al. Biomarkers of sarcopenia in clinical trials – Recommendations from the International Working Group on Sarcopenia. J Cachexia Sarcopenia Muscle 2012;3:181-190

23.   Cesari M. Role of gait speed in the assessment of older patients. JAMA 2011;305:93-94 [Editorial]

24.   Cesari M, Antonelli Incalzi R, Pahor M, Zamboni V. The vitamin D hormone: a multitude of actions potentially influencing the physical function decline in older persons. Geriatr Gerontol Int 2011;11:133-142

25.   Cesari M. The easiest way to predict adverse drug reactions in older persons. Arch Intern Med 2011;171:91-92

26.   Cesari M, Pahor M, Antonelli Incalzi R. Plasminogen Activator Inhibitor-1 (PAI-1): a key factor linking fibrinolysis and age-realted subclinical and clinical conditions. Cardiovasc Ther 2010;28:e72-91

27.   Cesari M, Pedone C, Antonelli Incalzi R, Pahor M. ACE inhibition and physical function – Results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors (TRAIN) study. J Am Med Dir Assoc 2010;11:26-32

28.   Cesari M, Marzetti E, Laudisio A, et al. Interaction of HDL cholesterol concentrations on the relationship between physical function and inflammation in community-dwelling older persons. Age Ageing 2010;39:74-80

29.   Cesari M, Kritchevsky SB, Atkinson HH, et al. ACE-inihibition and novel cardiovascular risk biomarkers – Results from the TRAIN study. Am Heart J 2009;157:334.e1-8

30.   Cesari M, Kritchevsky SB, Newman AB, et al. Added value of physical performance measures in predicting adverse health-related events. Results from the Health, Aging, and Body Composition study. J Am Geriatr Soc 2009;57:251-9

31.   Cesari M, Leeuwenburgh C, Lauretani F, et al. Frailty syndrome and skeletal muscle – Results from the InCHIANTI Study. Am J Clin Nutr 2006;83:1142-1148

32.   Cesari M, Kritchevsky SB, Baumgartner RN, et al. Sarcopenia, obesity, and inflammation – Results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors study. Am J Clin Nutr 2005;82:428-434

33.   Cesari M, Kritchevsky SB, Penninx BWHJ, et al. Lipoprotein peroxidation and onset of mobility disability. Results from the Health, Aging and Body Composition study. Arch Intern Med 2005;165:2148-2154

34.   Cesari M, Kritchevsky SB, Penninx BWJH, et al. Prognostic value of usual gait speed in well-functioning elders – Results from the Health, Aging and Body Composition (Health ABC) Study. J Am Geriatr Soc 2005;53:1675-1680

35.   Cesari M, Pahor M, Bartali B, et al Antioxidants and physical performance in older persons: the InCHIANTI study. Am J Clin Nutr 2004;79:289-294

36.   Cesari M, Penninx BWJH, Newman AB, et al. Inflammatory markers and onset of cardiovascular events: results from the Health ABC study. Circulation 2003;108:2317-2322

 

Selected research projects funded by public and private agencies

 

Ongoing research support

IMI-JU-09-2013                                                PI: Bernabei                                       7/1/2014-6/30/2020

Innovative Medicines Initiative (IMI) – 9th Call

"Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies (SPRINTT)”

SPRINTT aims at producing significant advancements in the prevention and therapy of physical frailty and sarcopenia (PF&S). Such objective will be pursued by developing and validating a robust definition of PF&S as a basis for evaluating and implementing specific multicomponent interventions for preventing the onset of mobility disability in older persons expressing precise functional, biological, and clinical characteristics. The funding of this 48-million euros project is equally shared by the European Commission and the European Federation of Pharmaceutical Industries and Associations (EFPIA; as in-kind funding).

Role: Leader of the Workpackage 2 (Clinical consensus over indication, target population and clinical trial design for data generation), Co-Investigator

 

Completed research support

#305483                                                             PI: Rodriguez Manas                      1/1/2013-12/31/2017

Seventh Framework Programme (FP7)

"Utility of omic-based biomarkers in characterizing older individuals at risk for frailty, its progression to disability and general consequences to health and well-being – The FRAILOMIC iniziative”

Aim of the project is to explore the biological foundation of the frailty syndrome in older persons in order to develop/improve clinical and research instruments capable of identifying individuals at higher risk of negative health-related events.

Role: Co-Investigator

 

#664291                                                             PI: Addis                                              1/1/2015-09/30/2017

Project Grants (HP-PJ) – 3RD EU Health Programme

“Reference sites network for prevention and care of frailty and chronic conditions in community dwelling persons of EU countries (SUNFRAIL)”

Aim of the project is to improve the identification, prevention and management of frailty and care of multimorbidity in community dwelling persons (over 65) in multiple loco-regional settings across several EU countries.

Role: Co-Investigator and Workpackage Leader

 

#662887                                                             PI: Rodriguez-Manas                     1/1/2015-06/30/2018

Project Grants (HP-PJ) – 3RD EU Health Programme

“A comprehensive validation of tools to screen and diagnose frailty in different clinical and social settings to provide instruments for integrated care in older adults (FRAILTOOLS)”

FRAILTOOLS aims to assess the usefulness as screening and diagnosis tools of some selected instruments to detect frailty in both clinical (Hospital and Primary Care) and social (nursing homes) settings, providing diagnostic algorithms clinically sound.

Target groups are all of those older adults at risk for frailty (pre-frail) plus those that are frail and are at risk for developing disability. According to the published prevalence of these two conditions, the target population concerned by this project represent around 40-50% of older people older than 65 and 60-70% of people older than 75.

Role: Co-Investigator and Workpackage Leader

 

CHEX_2011                                                       PI: Cesari                                             2/1/2012-1/30/2016

2011 Agence Nationale de la Recherche (ANR) Chairs of Excellence

"Multidomain Intervention to preveNt Disability in ElDers (MINDED)"

Scope of the study is to conduct a pilot study aimed at estimating the effects of a multidomain person-tailored intervention (based on physical activity, cognitive training, and nutritional modifications) on frailty status, physical performance, cognitive function, nutritional status, health-related quality of life, and use of health care services.

Role: Principal Investigator

 

N/A                                                                      PI: Cesari                                             2/15/2012-8/14/2013

Pfizer

"Incidence of pNeumonia and related ConseqUences in nursing home Residents (INCUR)"

Primary aims of the project are to estimate the incidence of pneumonia and the related healthcare costs in nursing home residents in France.

Role: Principal Investigator

 

 

 

 

N/A                                                                      PI: Cesari                                             11/1/2007-10/30/2010

Swiss Bridge Foundation (Zurich, Switzerland)

"Onco-geriatric approach for the management of oncological older patients"

Aim of the study is to assess whether assigning a geriatrician to provide daily medical care to older patients admitted to an oncological gynaecology ward can increase the number of patients eligible for a chemotherapeutic and/or surgical intervention.

Role: Principal Investigator

 

1 R01 AG026556-01A2                                  PI: Cesari                                             7/1/2007-6/30/2010

National Institute of Health-National Institute on Aging

"Oxidative damage, disability and mortality in elders"

Ancillary study to the Health, Aging and Body Composition study aimed at evaluating the predictive value of oxidative damage, platelet activation and inflammation for incident mobility disability and mortality in older persons.

Role: Principal Investigator

 

P30-AG-21332-03                                            PI: Pahor                                             10/1/2002-1/31/2005

National Institute of Health-National Institute on Aging

"Claude D. Pepper Older Americans Independence Centers"

The major goals of this project are the developing, testing and dissemination of effective therapies for the treatment and prevention of physical disability from chronic diseases in later life.

Role: Junior Investigator supported by the Research Career Development Core of the Wake Forest University Claude D. Pepper Older Americans Independence Center

 

N/A                                                                    PI: Cesari                                             6/1/2000-5/31/2005

Italian Ministry for University, Scientific Research and Technology (MURST)

“Topical treatment with Nerve Growth Factor for pressure ulcers”

A randomized double-blind, placebo-controlled trial designed to evaluate the effect of a topical treatment with Nerve Growth Factor for pressure ulcers in older persons.

Role: Principal Investigator